Nuevos Tratamientos para la Osteoporosis


2015-01-06   |   Climaterio

Consecuencias incluye disminución de la DMO, adelgazamiento de la cortical ósea,e incremento de la porosidad cortical y adelgazamiento trabecular, lo cual puede llevar a incrementar la fragilidad ósea.

The ultimate consequences of excessive bone remodeling include cortical bone thinning, increased cortical porosity, and trabecular thinning, which may lead to increased bone fragility.1,2

At the level of the bone, one mechanism underlying increased bone fragility because of increased remodeling may be the greater number of resorption sites, which give rise to areas of focal weakness.2

At the tissue level, increased bone remodeling translates into cortical bone thinning, increased cortical bone porosity, loss of trabecular elements, and thinning of trabecular elements, which contribute to increased bone fragility. Some osteoporosis treatments that decrease bone turnover, in particular, alendronate, have been shown to decrease cortical porosity, lead to more uniform mineralization of trabecular bone matrix, and improve indices of bone strength.3,4.


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